Riferimenti scientifici

Fonti scientifiche pubblicate nei più autorevoli giornali accademici e scientifici internazionali

1) Researchers at the UCLA School of Medicine found that Type 2 patients were able to reverse their diabetes in just three weeks by making small changes in their diet and adding moderate exercise. "The study shows, contrary to common belief, that Type 2 diabetes and metabolic syndrome can be reversed solely through lifestyle changes,"
according to lead researcher Dr. Christian K. Roberts. .

2) Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol, E. L. Lim & K. G. Hollingsworth & B. S. Aribisala & M. J. Chen & J. C. Mathers & R. Taylor. Diabetologia. DOI 10.1007/s00125-011-2204-7. The Newcastle University team has discovered that Type 2 diabetes can be reversed by diet alone.

3) Type 2 diabetes--time to change our approach. Lancet, 2010. 375(9733): p. 2193.

4) Barnard, N. D., Cohen, J., Jenkins, D. J. A., Turner-McGrievy, G., Gloede, L., Jaster, B., Seidl, K., Green, A. A., & Talpers, S. (2006). A Low-Fat Vegan Diet Improves Glycemic Control and Cardiovascular Risk Factors in a Randomized Clinical Trial in Individuals With Type 2 Diabetes. Diabetes Care , 29 (8), 1777-1783.

5) Knowler, W. C., Barrett-Connor, E., Fowler, S. E., Hamman, R. F., Lachin, J. M., Walker, E. a, et al. (2002). Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. The New England journal of medicine, 346(6), 393-403. doi: 10.1056/NEJMoa012512.

6) Crane, MG and Sample, C: Regression of diabetic neuropathy with total vegetarian (vegan) diet. J Nutr Med 1994; 4:431-439.

7) Parekh P, Petro A, Tiller J, Feinglos M, Surwit R. Reversal of diet-induced obesity and diabetes in C57BL/6J Mice. Metabolism 1998;47, 9:1-8.

8) Anderson, JW and Ward, K: High Carbohydrate, High fiber diets for insulin-treated men with diabetes mellitus. Am J Clin Nutr, 1979; 32:2312-21. "Medical research confirms that up to 50% of Type 2 diabetics can eliminate diabetes risks and discontinue medication within three weeks by adopting a low-fat, plant food diet and regular daily exercise."

9) Purnell JQ. Effect of excessive weight gain with intensive therapy of type 1 diabetes on lipid levels and blood pressure: results from the DCCT. Diabetes Control and Complications Trial. JAMA. 1998 Jul 8;280(2):140-6.

10) Colwell JA, Clark CM Jr. Forum Two: Unanswered research questions about metabolic control in non-insulin-dependent diabetes mellitus. Ann Intern Med. 1996 Jan 1;124(1 Pt 2):178-9.

11) Gustafsson I, Hildebrandt P, Seibaek M, Melchior T, Torp-Pedersen C, Kober L, Kaiser-Nielsen P. Long-term prognosis of diabetic patients with myocardial infarction: relation to antidiabetic treatment regimen. The TRACE Study Group. Eur Heart J. 2000 Dec;21(23):1937-43.

12) Duckworth W, Abraira C, Moritz T, Reda D, Emanuele N, Reaven PD, Zieve FJ, Marks J, Davis SN, Hayward R, Warren SR, Goldman S, McCarren M, Vitek ME, Henderson WG, Huang GD; the VADT Investigators. Glucose Control and Vascular Complications in Veterans with Type 2 Diabetes. N Engl J Med. 2008 Dec 17. [Epub ahead of print]

13) Action to Control Cardiovascular Risk in Diabetes Study Group, Gerstein HC, Miller ME, Byington RP, Goff DC Jr, Bigger JT, Buse JB, Cushman WC, Genuth S, Ismail-Beigi F, Grimm RH Jr, Probstfield JL, Simons-Morton DG, Friedewald WT. Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med. 2008 Jun 12;358(24):2545-59.

14) ADVANCE Collaborative Group, Patel A, MacMahon S, Chalmers J, Neal B, Billot L, Woodward M, Marre M, Cooper M, Glasziou P, Grobbee D, Hamet P, Harrap S, Heller S, Liu L, Mancia G, Mogensen CE, Pan C, Poulter N, Rodgers A, Williams B, Bompoint S, de Galan BE, Joshi R, Travert F. Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med. 2008 Jun 12;358(24):2560-72.

15) Hinsworth HP. Diet in the aetiology of diabetes. Proc R Soc Med 1949;42:323-6

16) West KM, Kalbfleisch JM,. Influence of nutritional factors on prevalence of diabetes. Diabetes 1971; 20: 99-108.

17) Rao RH. The role of undernutrition in the pathogenesis of diabetes mellitus. Diabetes Care 1984; 7: 595-601.

18) Joslin EP. Atheroscleriosis and diabetes. Ann Clin Med 1927;5:1061.

19) Barnard, N. D., Cohen, J., Jenkins, D. J. A., Turner-McGrievy, G., Gloede, L., Jaster, B., Seidl, K., Green, A. A., & Talpers, S. (2006). A Low-Fat Vegan Diet Improves Glycemic Control and Cardiovascular Risk Factors in a Randomized Clinical Trial in Individuals With Type 2 Diabetes. Diabetes Care , 29 (8), 1777-1783.

20) Barnard RJ, Lattimore L, Holly RG, Cherny S, Pritikin N. Response of non-insulindependent diabetic patients to an intensive program of diet and exercise. Diabetes Care. 1982;5(4):370-4

21) Acceptance is growing among the mainstream medical community that diabetes is reversible. Dr. Mehmet Oz is among the many physicians who now say diabetes is completely reversible by making better lifestyle choices. As reported on Oprah.com, Dr. Oz stated: “Ninety percent of type 2 diabetics can actually reverse their problem.” http://www.drcredeur.com/diabetes/what-does-dr-oz-say-about-diabetes

22) “Reversing diabetes is possible” by Val Willingham, CNN. Bethesda, Maryland (CNN) -- Diabetes type-2 can be reversed. "We have seen numerous people reverse their condition," says Dr. Michelle Magee, director of the MedStar Diabetes Institute in Washington. "But it takes a real dedication for the rest of their lives," she notes. http://www.cnn.com/2011/HEALTH/01/28/reverse.diabetes/index.html

23) UK Study shows diabetes is reversible. June 28, 2011 Researchers from Newcastle University have clearly shown that diet alone can actually reverse the condition by normalizing blood glucose levels, reducing cholesterol levels and even stimulate the pancreas’s insulin producing cells (beta cells) to return to normal! The full study was published in the June issue of the journal Diabetologia. http://hadleywoodhealthcare.wordpress.com/2011/06/28/diabetes-is-reversible

24) Type 2 Diabetes Reversible Friday, June 24, 2011. Reversal Of Type 2 Diabetes: Normalisation Of Beta Cell Function In Association With Decreased Pancreas And Liver Triacylglycerol, Diabetologia, June 9, 2011. The authors wrote, “Normalisation of both beta cell function and hepatic insulin sensitivity in type 2 diabetes was achieved by dietary energy restriction alone. This was associated with decreased pancreatic and liver triacylglycerol stores. The abnormalities underlying type 2 diabetes are reversible by reducing dietary energy intake”. http://www.ncbi.nlm.nih.gov/pubmed/21656330

25) Mainstream media acknowledges diabetes can be reversed through major diet, lifestyle changes. Monday, February 07, 2011 by: Ethan A. Huff, staff writer (NaturalNews): The mainstream media is just now catching on to what NaturalNews and other natural health advocates have been saying for years: type 2 diabetes can be reversed through dietary and lifestyle changes, and without the need for lifelong drug interventions. A recent report by CNN says that improving one's diet, keeping off excess weight, and regularly exercising, can help millions of people with diabetes get rid of it for good. http://www.naturalnews.com/031233_diabetes_lifestyle.html http://truthonmedecine.wordpress.com/2011/02/07/mainstream-media-admits-diabetes-can-be-reversed-through-major-diet-lifestyle-changes/

26) The majority of cases of type 2 diabetes can be prevented by the adoption of a healthier lifestyle. Sept 2001. In a report in The New England Journal of Medicine, Walter Willett, MD, PhD, and his colleagues from the Harvard School of Public Health demonstrated that 91 percent of all Type 2 diabetes cases could be prevented through improvements lifestyle and diet. Frank B. Hu, M.D., JoAnn E. Manson, M.D., Meir J. Stampfer, M.D., Graham Colditz, M.D., Simin Liu, M.D., Caren G. Solomon, M.D., and Walter C. Willett, M.D.N Engl J Med 2001; 345:790-797 September 13, 2001 http://www.nejm.org/toc/nejm/345/11 September 13, 2001

27) Diabetes And Insulin Resistance Are Reversible. Huffington Post August 8, 2009 Dr. Mark Hyman says type 2 diabetes is reversible with early intervention and a proper diet. http://www.healthiertalk.com/are-diabetes-and-insulin-resistance-really-reversible-0839

28) 11 People (55%) Reversed Type 2 Diabetes. American Journal of Clinical Nutrition. August 17, 2010 by Robby. A peer reviewed study demonstrates 11 people (55%) of the patients reversed type 2 diabetes in an average of 16 days.Anderson, J. W., & Ward, K. (1979). High-carbohydrate, high-fiber diets for insulin-treated men with diabetes mellitus. American Journal of Clinical Nutrition, 32, 2312-2321. The abstract is available to the public at this link http://www.ajcn.org/content/32/11/2312.abstract

29) Engineer proves diabetes is reversible with plant-based diet. February 21, 2006 Rochester Democrat & Chronicle Xerox engineer reversed his diabetes and got off insulin by following a strict plant-based diet of vegetables, legumes, fish, and plant oils. PDF file of newspaper article: http://www.democratandchronicle.com/apps/pbcs.dll/article?AID=/20060215/LIVING/602150311

30) Diabetes is not necessarily a one-way street. PCRM Clinical Research. February 15, 2005 Diabetes: Can a Vegan Diet Reverse Diabetes? By Andrew Nicholson, M.D. Early studies suggest that persons with type 2 diabetes can improve and, in some cases, even reverse the disease by switching to an unrefined, vegan diet. This is based on a carefully controlled test performed by PCRM (Physicians Committee for Responsible Medicine). http://www.pcrm.org/health/clinres/diabetes.html

31) Working with Georgetown University, PCRM compared two different diets: a high-fiber, low-fat, vegan diet and the more commonly used American Diabetes Association (ADA) diet.

32) Fasting blood sugars decreased 59 percent more in the vegan group than in the ADA group. And, while the vegans needed less medication to control their blood sugars, the ADA group needed just as much medicine as before. The vegans were taking less medicine, but were in better control. While the ADA group lost an impressive 8 pounds, on average, the vegans lost nearly 16 pounds. Cholesterol levels also dropped more substantially in the vegan group compared to the ADA group.

33) Medical research confirms lifestyle change can reverse diabetes. December 21, 1979. Medical research confirms that up to 50% of people with Type 2 diabetes can eliminate diabetes risks and discontinue medication within three weeks by adopting a low-fat, plant food diet and regular daily exercise. Anderson, JW and Ward, K: High Carbohydrate, High fiber diets for insulin-treated men with diabetes mellitus. Am J Clin Nutr, 1979; 32:2312-21.http://www.newstart.com/conditions/reverse-diabetes/

34) Software executive cures himself of diabetes at the age of 30. Mike Adams, now known as the Health Ranger, cured himself of diabetes in a matter of months and transformed himself into the picture of perfect health in mind, body and spirit. Mike dove into research; he devoured thousands of books on nutrition, pharmaceutical drugs, wellness programs, the politics of food - anything he could find. Mike has now made it his life mission to share the most remarkable discovery he made on his quest: the vast majority of all diseases can be easily prevented and even cured without drugs or surgery. http://www.healthranger.org/bio.html

35) Diabetes is reversible. Mayo Clinic. Potentially reversible diabetes conditions include prediabetes — when your blood sugar levels are higher than normal, but not high enough to be classified as diabetes — and gestational diabetes, which occurs during pregnancy. http://www.mayoclinic.com/health/diabetes/DS01121

36) “Diabetes is 100 percent reversible." Dr. Mercola, Sept. 2008. Diabetes is virtually curable for anyone who is willing to put in the hard time and work and recovering their insulin and leptin sensitivity http://articles.mercola.com/sites/articles/archive/2011/03/03/media-finally-states-reversing-diabetes-is-possible.aspx

37) The Diabetes Conundrum: What Physicians Are Teaching You May be Killing You - Read the surprising conclusion Dr. Rosedale, one of the leading diabetic doctors in the country, reaches about the current state of knowledge in diabetes. http://articles.mercola.com/sites/articles/archive/2005/06/21/diabetes-part-fifteen.aspx

38) The Rosedale diet: The real "cure" for diabetes is to eat a diet that promotes insulin and leptin sensitivity. http://articles.mercola.com/sites/articles/archive/2005/08/16/doctors-cause-diabetics-to-die.aspx

39) “No matter how long you have lived with diabetes, your experience of life can become better than you ever imagined.” http://www.thetruenature.net/diabetes DR. RON ROSEDALE SPEAKS ON DIABETES: "The increased incidence in diabetes is as shocking as it is alarming. This is a disease that should be very rare, yet it is commonplace, even among children, and rapidly escalating. At one time, type 2 diabetes was called senile diabetes, a reflection of the fact that it usually did not affect people until they were well into their late decades. As more and more middle-age people began to develop this disease, the name was changed to adult-onset diabetes (no one middle-age wants to be called senile!!). Given the fact that so many children are now getting adult-onset diabetes, medicine has once again stuck a name onto a so-called new disease--MODY, Maturity-Onset Diabetes of the Young. This is a prime example of how the so-called diseases of aging are not related solely to chronological age but to overall health. "Type 1 diabetes (also called juvenile diabetes) is a result of too little insulin, the hormone that is produced in response to rising blood glucose or sugar levels. Without enough insulin, blood sugar levels can clim dangerously high, leading to organ damage and death. Type 2 diabetes (discussed in the paragraph above), is an entirely different story and accounts for about 95 percent ofall cases of adult diabetes. Type 2 diabetes is characterized by a condition called insulin resistance, which occurs when the cells of the body are constantly exposed to high levels of insulin. Plenty of insulin is being made, but cells have become desensitized. In the case of type 2 diabetes, the cause is more closely linked to a failure in cellular communication; that is, how well your cells can 'listen' to insulin and leptin, than your age. "When your cells become resistant to insulin, the receptors con cell membranes no longer 'hear' the signals from insulin. This can cause catastrophic health problems down the road, including blood lipid abnormalities, high blood ressure, heart disease and even cancer. "Insulin resistance often goes hand in hand with elevated leptin levels and leptin resistance, and both conditions are linked to eating too much of the wrong food. Lower your leptin levels and your insulin problems willgreatly improve. Leptin resistance results in deep pockets of fat in the waist and abdomen which 'smother' the liver from receiving proper hormonal signals, a very important one being from insulin. When your liver becomes insulin resistant, it will make too much sugar, contributing to insulin resistance and diabetes. Elevated leptin also increases fight-or-flight mode, which boosts blood glucose levels and production of cortisol (stress hormone) by the adrenal glands, which causes blood glucose levels to soar even higher.

40) Natural Treatments For Diabetes: The Whitaker Wellness approach is very effective in reducing and often eliminating the need for oral diabetes drugs and insulin in patients with type 2 diabetes.

41) The Whitaker Wellness Institute’s approach to diabetes is twofold: to lower blood sugar and to reduce the risk of diabetic complications with diet, exercise, and targeted nutritional supplements.

42) Diabetes Can Be Treated Without Drugs: Julian Whitaker, MD; Jul 03, 2009. "Hundreds of clinical trials demonstrate that diabetes can not only be prevented but actually reversed -- not with drugs but with simple, inexpensive lifestyle measures." http://adrianbridgwater.sys-con.com/node/1024164

43) Health and Medicine: Dr. Neal Barnard's Program for Reversing Diabetes (a vegan diet w/ low GI foods) outlines a nutritional approach to treating diabetes, citing the examples of study participants who successfully improved their ability to respond to insulin, lost weight, and ended medication dependency. http://www.nealbarnard.org/ http://diabeticdietzone.com/blog/blood-glucose-diabetes/dr-neal-barnards-program-for-reversing-diabetes-the-scientifically-proven-system-for-reversing-diabetes-without-drugs http://www.pcrm.org/about/events/india.html

44) The Diabetes Prevention Program study, a very large randomized clinical trial , by Deborah Greenwood, MEd, CNS, BC-ADM, CDE: (the most accurate study design) showed that you could reduce the development of diabetes by 58% by doing some simple things. 1. Lose 5-10% of your body weight by eating healthy, with calorie and fat reduction (only 25% of calories from fat). 2. Engage in physical activity for at least 30 minutes five times per week. These changes can significantly reduce the risk of developing diabetes. Other studies have looked at other types of weight loss such as using meal replacements. The global consensus is that if you lose weight and keep it off, you may be able to prevent diabetes as well as improve blood pressure and lab values.

45) Raw for 30 Days is an independent documentary film by Dr Gabriel Cousens entitled: 'Reverse Diabetes in 30 Days' that chronicles six Americans with diabetes who switch to a diet consisting entirely of vegan, organic, live, raw foods in order to reverse diabetes naturally.A medical team was established to monitor various health variables of the subjects. The diet: "No meat, no dairy, no alcohol, no caffeine, no refined foods, no junk food or fast food of any kind, no candies, no sugar". Conclusion: Type 2 diabetes can be cured, or at least drastically reduce blood sugar, hemnoglobin a1c, blood pressure, cholesterol, weight, etc. http://www.rawfor30days.com/themovie.html "Dr Cousens’ Reversing Diabetes Naturally Protocol is a medically-supervised nutritional therapy program for type 1 and type 2 diabetics, as well as pre-diabetics who do not want to live their lives codependent to Insulin and other medication drugs. Supported by scientific research, Dr. Cousens’ clinical results make this protocol the most comprehensive and successful diabetes reversing programs in the world." http://www.gabrielcousens.com/drnewhome/88PROGRAMS/REVERSINGDIABETESPROGRAM/tabid/1923/language/en-US/Default.aspx

46) DR GABRIEL COUSENS SPEAKS ON DIABETES: "In one to four days practically we get people off all their insulin and all their other diabetic medications and in 2 to 3 weeks, even if their blood sugar starts at 500 or 400, returning their blood sugar to normal which is less than a hundred." http://youtu.be/0viz3jej1w0

47) A randomized trial of a church-based diabetes self-management program for African Americans with type 2 diabetes. Samuel-Hodge CD, Keyserling TC, Park S, Johnston LF, Gizlice Z, Bangdiwala SI. Diabetes Educ. 2009 May-Jun;35(3):439-54. Epub 2009 Apr 21. CONCLUSIONS: The church-based intervention was well received by participants and improved short-term metabolic control.

48) Reduction in risk factors for type 2 diabetes mellitus in response to a low-sugar, high-fiber dietary intervention in overweight Latino adolescents. Ventura E, Davis J, Byrd-Williams C, Alexander K, McClain A, Lane CJ, Spruijt-Metz D, Weigensberg M, Goran M. Arch Pediatr Adolesc Med. 2009 Apr;163(4):320-7.

49) A low-fat vegan diet elicits greater macronutrient changes, but is comparable in adherence and acceptability, compared with a more conventional diabetes diet among individuals with type 2 diabetes. Barnard ND, Gloede L, Cohen J, Jenkins DJ, Turner-McGrievy G, Green AA, Ferdowsian H. J Am Diet Assoc. 2009 Feb;109(2):263-72.

50) Effect of a low-glycemic index or a high-cereal fiber diet on type 2 diabetes: a randomized trial. Jenkins DJ, Kendall CW, McKeown-Eyssen G, Josse RG, Silverberg J, Booth GL, Vidgen E, Josse AR, Nguyen TH, Corrigan S, Banach MS, Ares S, Mitchell S, Emam A, Augustin LS, Parker TL, Leiter LA. JAMA. 2008 Dec 17;300(23):2742-53. In patients with type 2 diabetes, 6-month treatment with a low-glycemic index diet resulted in moderately lower HbA(1c) levels compared with a high-cereal fiber diet.

51) Glucose and insulin responses to whole grain breakfasts varying in soluble fiber, beta-glucan: a dose response study in obese women with increased risk for insulin resistance. Kim H, Stote KS, Behall KM, Spears K, Vinyard B, Conway JM. Eur J Nutr. 2009 Apr;48(3):170-5. Epub 2009 Feb 5. CONCLUSION: These data suggest that acute consumption of 10 g of beta-glucan is able to induce physiologically beneficial effects on postprandial insulin responses in obese women at risk for insulin resistance.

52) Effects of antioxidant supplementation on insulin sensitivity, endothelial adhesion molecules, and oxidative stress in normal-weight and overweight young adults. Vincent HK, Bourguignon CM, Weltman AL, Vincent KR, Barrett E, Innes KE, Taylor AG. Metabolism. 2009 Feb;58(2):254-62. Antioxidant supplementation moderately lowers HOMA and endothelial adhesion molecule levels in overweight young adults. A potential mechanism to explain this finding is the reduction in oxidative stress by AOX.

53) Anti-inflammatory effect of lifestyle changes in the Finnish Diabetes Prevention Study. Herder C, Peltonen M, Koenig W, Sütfels K, Lindström J, Martin S, Ilanne-Parikka P, Eriksson JG, Aunola S, Keinänen-Kiukaanniemi S, Valle TT, Uusitupa M, Kolb H, Tuomilehto J; Finnish Diabetes Prevention Study Group. Diabetologia. 2009 Mar;52(3):433-42. Epub 2009 Jan 8. CONCLUSIONS/INTERPRETATION: The present study assessed the individual effects of dietary and physical activity measures on low-grade inflammation in individuals at high cardiometabolic risk. Our results underline the importance of moderate to vigorous LTPA and a diet rich in natural fibre, and this should be emphasised in lifestyle recommendations.

54) One-year comparison of a high-monounsaturated fat diet with a high-carbohydrate diet in type 2 diabetes. Brehm BJ, Lattin BL, Summer SS, Boback JA, Gilchrist GM, Jandacek RJ, D'Alessio DA. Diabetes Care. 2009 Feb;32(2):215-20. Epub 2008 Oct 28. CONCLUSIONS: In individuals with type 2 diabetes, high-MUFA diets are an alternative to conventional lower-fat, high-CHO diets with comparable beneficial effects on body weight, body composition, cardiovascular risk factors, and glycemic control.

55) Dietary Calcium and Magnesium Intakes and the Risk of Type 2 Diabetes: the Shanghai Women's Health Study. Villegas R, Gao YT, Dai Q, Yang G, Cai H, Li H, Zheng W, Shu XO. Vanderbilt Epidemiology Center, Department of Medicine, Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center, Nashville, TN, and the Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China.

56) PCRM study published in Diabetes Care in 2006, found that participants on a vegan diet experienced significantly greater reductions in A1c (a measure of blood sugar levels over a prolonged period), weight, body mass index, waist circumference, and LDL (“bad”) cholesterol. Neal Barnard, M.D. http://www.pcrm.org/news/nejm.html

57) China Study supports a plant-based diet that can prevent heart disease, diabetes, and some cancers. The China Study:The Most Comprehensive Study of Nutrition Ever Conducted and the Startling Implications for Diet, Weight Loss and Long-term Health (2005). Dr. T. Colin Campbell, Ph.D., Nutritional Biochemistry Cornell University. Note: The China Study was the culmination of a 20-year partnership of Cornell University, Oxford University and the Chinese Academy of Preventive Medicine.

58) Dr. Richard K. Bernstein, M.D., F.A.C.E., F.A.C.N., C.W.S., FACCWS. Offers a complete guide to achieving normal blood sugars.



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